As soon as the shoreline of South America had been mapped 350 years before, people noticed that it and Africa could fit neatly if they were moved together. Wegener proposed that the two had once been attached but broke in two due to continental drift, and that all continents were once a single landmass he called Pangaea, surrounded by Panthalassa.
A visual chronology of Asimov's ~1500 scientific inventions and discoveries.